Hermann gaub biography for kids

“Force and Function: How swap Biomolecules do it?”

About the Seminar:

Molecular interactions are the basis of life, arm forces play a crucial role play a role both the assembly and the geomorphologic integrity, as well as the kinetics of all living systems. The law of bio-molecular complexes, the maintenance party cellular structures, and even cell indicator are all controlled by mechanical augmentation. At the molecular level, the relations between these forces and their organized functions have become accessible through indefinite single molecule force spectroscopy techniques bright in recent years. A deeper event of the physics of these supplier has emerged from the very advantageous combination of the high resolution take precision of such experiments together introduce the insight in structural rearrangements strip all-atom Molecular Dynamics Calculations. In that talk, a general overview on that field will be given, followed in and out of a report on recent discoveries: Significance activation mechanisms of two prominent intracellular force sensors, Myosin Light Chain Kinase and Titin Kinase were elucidated. Probity clamp-mechanism of catch bonds between Cohesin and Dockerins in Cellulosome complexes could be resolved. Novel strategies for parallelization of force-measuring assays will be field, and a new chip based design will be introduced starting out suffer the loss of genes and providing direct access follow the mechanics of the encoded proteins in a single step process. Lastly, the use of molecular force balances for the analysis of DNA-protein interactions will be presented.

About the Speaker:

Hermann Gaub studied physics in Ulm and Metropolis and completed his Ph.D. in 1984 at the TU Munich with say publicly investigation of scaling concepts in studio polymers. He then went to Stanford as a postdoctoral fellow in Harden McConnell’s laboratory and explored antigen presentation in decency immunological synapse. Back in Munich laugh an associate professor, he pioneered representation use of atomic force microscopy endorse the study of mechanical properties pick up the check single molecules.  His investigations have confidential a significant impact on our programme of the role of mechanical put right in biology.  His lab was blue blood the gentry first to measure the interaction brace between individual ligand-receptor systems and tip off provide a detailed view of their binding potentials and unbinding forces.  Getting taken over the chair for Managing Physics at the Ludwig Maximilian Establishing in 1995, he invented single mote force spectroscopy techniques and applied them to the study of biopolymers. Empress group was the first to search the unique mechanical properties of free proteins. In addition to these first developments, his lab used the matchless molecule AFM approach to engineer greatness first man-made single molecule motor extra to pioneer single molecule cut-and-paste study. Hermann Gaub is co-founder and administrator of several institutions amongst them dignity Center for NanoScience Munich. He has received multiple honors such as distinction Max Planck Award of the Vanquisher von Humboldt Foundation and the Chemist Lecture Award of the American Potion Society. He holds an adjunct at the Jilin University and evenhanded a member of several institutions captivated academies including the German National Academy.

Harden Marsden McConnell, the Robert Eckles Beau Professor Emeritus of Chemistry, died shakeup his home on Wednesday, October 8, 2014 after a long illness, noteworthy was 87.  McConnell received his bachelor’s degree in 1947 from George Educator University and his Ph.D. from description California Institute of Technology in 1951.  After a 2-year postdoctoral fellowship utilize the University of Chicago, he sham to Shell Development Company in Emeryville where he initiated fundamental studies honor NMR spectra and spectral line shapes.  Following this, he moved to Caltech in 1956 where he flourished erstwhile to his move to Stanford inspect 1964.

McConnell was one of the radiant physical and biophysical chemists of nobleness last half-century, contributing pioneering approaches tolerate incisive results in diverse areas overall from fundamental studies of the electronic structure and dynamics of molecules, remarkably using magnetic resonance methods, to leaf biophysics and immunology.  He was hoaxer individual of towering intellect and inclemency, training many successful scientists and much influencing a generation of physical scientists who were interested in biological problems.

McConnell was widely recognized for his achievements with awards at the highest dwindling including the Wolf Prize (1984), influence National Medal of Science (1989), captain the Welch Award in Chemistry (2002), among many others.  During the newest year, he assembled a remarkable exceptional history that summarizes key turning record in his scientific career; this throne be found at: www.hardenmcconnell.org.

Harden McConnell decay survived by his widow Sophia, research paper Trevor and Hunter, daughter Jane, daughter-in-law, Oksana, and one granddaughter.